Old age or cognitive decline? Examining the usability of a mobile health app for older Australians.

There is a growing literature on the role of mobile health applications (mHealth apps) in supporting older adults and the self-management of personal health. The purpose of this pilot study is to assess the usability of a government-funded mobile health app amongst older Australians and to evaluate whether cognitive function and demographic characteristics (i.e. age, gender, education) are associated with usability. A total of 28 older adults living in a regional city in Australia took part in the study. The participants were recruited using purposive sampling. Data collection instruments consisted of validated cognitive tests, task-based usability tests, and a questionnaire. The data was analyzed using non-parametric strategies. The findings of this study demonstrated that a government-funded, mHealth app was usable by older adults. Users were able to perform basic tasks in an effective and efficient manner. The hypothesis that elderly age would be significantly associated with performance on cognitive tests, as well as usability, was not supported. Performance on some cognitive tests was significantly and positively related to usability. Education and gender were not related to usability. The results suggest that traditional stereotypes surrounding aging and cognitive decline need to be reexamined.

Experience of loneliness on well-being among young individuals: A systematic scoping review.

A systematic scoping review was conducted to explore the current evidence on the experience of loneliness influencing well-being among youths. The electronic databases Scopus, APA PsycINFO, Emerald Insight and One Search were used to identify relevant studies, followed by an analysis of the text words contained in the title and abstract, and of the index terms used to describe the article. Reference lists of all shortlisted articles were searched for additional studies. 20 studies (quantitative, qualitative and mixed) published in the English language were identified for inclusion. Findings illustrate that the experience of loneliness is a complex, evolutionary process influenced by relational and environmental factors. Results from the studies identified factors that promote lower experience of loneliness and better well-being in future life stages. Future research can substantiate the issues related to young individuals being socially isolated from others for a prolonged duration.

The Role of Religiosity and Guilt in Symptomatology and Outcome of Obsessive Compulsive Disorder.

Importance: Religiosity and guilt are commonly featured in obsessive-compulsive disorders (OCD). The role of religiosity and guilt in OCD has been frequently studied in the literature and suggested that greater religiosity/spirituality, paranormal beliefs, and magical ideation have often been associated with enhanced obsessive-compulsive behavior. India being a multi-religious country, it is particularly notable that a research was required to assess the role of religiosity and guilt in symptomatology and outcome in OCD, a condition in which religious themes are often present. It has also been documented that the fear of guilt for doing something irresponsibly may lead to OCD symptoms. Objective: The study aimed to seek the role of religiosity and guilt in symptomatology and outcome of OCD. This study also aimed to assess the pattern of symptomatology of patients with OCD and the relation between religiosity and guilt. Settings and Design: This was a single-centered, prospective study for one year with six months follow-up. Methods and Material: Fifty OCD subjects of either gender, aged between 18 years and 45 years were included in this study and were assessed using Yale-Brown Obsessive Compulsive Scale, Belief into Action Scale, and The Guilt Inventory instruments for the measurement of OCD severity, religiosity, and guilt, respectively. All the recorded data were analyzed using IBM® SPSS® version 20.1. Results: At baseline, OCD severity was positively correlated with religiosity and guilt, while after 6-month follow-up, OCD severity was negatively correlated with religiosity and positively correlated with guilt. Conclusion: Religiosity and guilt have significant effect on the symptomatology and outcome of OCD.

Bioaccumulation potential of indigenous plants for heavy metal phytoremediation in rural areas of Shaheed Bhagat Singh Nagar, Punjab (India).

The present study was planned to explore the bioaccumulation potential of 23 plant species via bioaccumulation factor (BAf), metal accumulation index (MAI), translocation potential (Tf), and comprehensive bioconcentration index (CBCI) for seven heavy metals (cadmium, chromium, cobalt, copper, iron, manganese, and zinc). The studied plants, in the vicinity of ponds at Sahlon: site 1, Chahal Khurd: site 2, and Karnana: site 3 in Shaheed Bhagat Singh Nagar, Punjab (India), were Ageratum conyzoides (L.) L., Amaranthus spinosus L., Amaranthus viridis L., Brassica napus L., Cannabis sativa L., Dalbergia sissoo DC., Duranta repens L., Dysphania ambrosioides (L.) Mosyakin & Clemants, Ficus infectoria Roxb., Ficus palmata Forssk., Ficus religiosa L., Ipomoea carnea Jacq., Medicago polymorpha L., Melia azedarach L., Morus indica L., Malva rotundifolia L., Panicum virgatum L., Parthenium hysterophorus L., Dolichos lablab L., Ricinus communis L., Rumex dentatus L., Senna occidentalis (L.) Link, and Solanum nigrum L. BAf and Tf values showed high inter-site deviations for studied metals. MAI values were found to be more substantial in shoots as compared with that of roots of plants. Maximum CBCI values were observed for M. azedarach (0.626), M. indica (0.572), D. sissoo (0.497), and R. communis (0.474) for site 1; F. infectoria (0.629), R. communis (0.541), D. sissoo (0.483), F. palmata (0.457), and D. repens (0.448) for site 2; D. sissoo (0.681), F. religiosa (0.447), and R. communis (0.429) for site 3. Although, high bioaccumulation of individual metals was observed in herbs like C. sativa, M. polymorpha, and Amaranthus spp., cumulatively, trees were found to be the better bioaccumulators of heavy metals.

Perception, action, and Roelofs effect: a mere illusion of dissociation.

A prominent and influential hypothesis of vision suggests the existence of two separate visual systems within the brain, one creating our perception of the world and another guiding our actions within it. The induced Roelofs effect has been described as providing strong evidence for this perception/action dissociation: When a small visual target is surrounded by a large frame positioned so that the frame's center is offset from the observer's midline, the perceived location of the target is shifted in the direction opposite the frame's offset. In spite of this perceptual mislocalization, however, the observer can accurately guide movements to the target location. Thus, perception is prone to the illusion while actions seem immune. Here we demonstrate that the Roelofs illusion is caused by a frame-induced transient distortion of the observer's apparent midline. We further demonstrate that actions guided to targets within this same distorted egocentric reference frame are fully expected to be accurate, since the errors of target localization will exactly cancel the errors of motor guidance. These findings provide a mechanistic explanation for the various perceptual and motor effects of the induced Roelofs illusion without requiring the existence of separate neural systems for perception and action. Given this, the behavioral dissociation that accompanies the Roelofs effect cannot be considered evidence of a dissociation of perception and action. This indicates a general need to re-evaluate the broad class of evidence purported to support this hypothesized dissociation.

Distribution of protein nitrotyrosine in synovial tissues of patients with rheumatoid arthritis and osteoarthritis.

OBJECTIVE: Because nitric oxide related species have been found in the inflamed joints of patients with arthritis, we investigated whether protein nitrotyrosine (a marker of tissue exposure to peroxynitrite) is present in their synovial tissues. METHODS: Protein nitrotyrosine was detected immunohistochemically and by Western blot analysis. Synovial tissues removed surgically from 12 patients with rheumatoid arthritis (RA) (mean age 63.7 yrs) and 20 with osteoarthritis (OA) (mean age 66.6 yrs) were studied. RESULTS: Nitrated proteins were detected immunohistochemically in all of 18 tissues examined. Diffuse staining of the stroma was seen in all patients, with more extensive staining in RA than OA (p = 0.008). Intense staining was detected in some lymphocytes, but not in others, even within a single lymphoid aggregate. Neutrophils did not stain for nitrotyrosine. Vascular endothelial cells stained for nitrotyrosine but adjoining smooth muscle cells did not. Both cytoplasmic and nuclear staining was seen in macrophages, endothelial cells, and lymphocytes. Numerous bands of nitrated proteins were detected by Western blot analysis of 15 synovial tissue extracts. Inducible nitric oxide synthase (iNOS) was detected immunohistochemically in endothelial cells, macrophages, vascular smooth muscle cells, and synoviocytes. CONCLUSION: Nitrotyrosine-containing proteins were found in essentially all synovia from RA and OA patients. The most prominent site of nitration in all cases was the stroma. iNOS, the likely source of the nitrating species, was found in a variety of cell types.